Select a chapter 1 - Clinical hematology: Benign disorders 1 - Pathophysioloy 1 - Clinical hematology: Benign disorders 2 - Clinical hematology: Myeloid malignancies 2 - Epidemiology and natural history 2 - Clinical hematology: Myeloid malignancies 3 - Clinical hematology: Lymphoid malignancies and plasma cell disorders 3 - Diagnosis 3 - Clinical hematology: Lymphoid malignancies and plasma cell disorders 4 - Treatment of hematological disorders 4 - Screening 4 - Treatment of hematological disorders 5 - Laboratory diagnosis 5 - Acute complications 5 - Laboratory diagnosis 6 - Thrombosis and hemostasis 6 - Chronic complications 6 - Thrombosis and hemostasis 7 - Transfusion medicine 7 - Pediatric management 7 - Transfusion medicine 8 - General skills 8 - Transition from pediatric to adult services 8 - General skills 9 - Obstetric management 10 - Perioperative management 11 - The older patient 12 - Psychological factors 13 - Social and environmental factors 14 - Vaccination and prophylaxis against infection 15 - Primary stroke prevention 16 - Hydroxyurea 17 - Blood transfusion 18 - Hematolopoietic stem cell transplantation (HSCT) 19 - Emerging treatments 20 - Sickle cell disease in low and middle-income countries 21 - HbSC disease 22 - HbS/Beta thalassemia 23 - Other types of sickle cell disease 24 - Sickle cell carriers

Select a subchapter 1A - Red cell and iron disorders 1B - Bone marrow failure 1C - Non-malignant white blood cell disorders 1D - Platelet disorders and angiopathies 1E - Consultative hematology Select a subchapter 1A - Structure and function of alpha, beta and gamma globin gene families 1B - Structure and function of normal hemoglobin 1C - Hemoglobin S polymerization 1D - Vaso-occlusion 1E - Red cell cation loss and dehydration 1F - Hemolysis 1H - Hypercoagulability 1I - Platelet activation 1J - Increased and altered expression of adhesion molecules 1K - Oxidative stress and reperfusion injury 1L - Abnormal red cell rheology 1M - HbF levels 1N - Alpha thalassemia 1O - Glucose-6-phosphate dehydrogenase deficiency Select a subchapter 1A - Red cell and iron disorders 1B - Bone marrow failure 1C - Non-malignant white blood cell disorders 1D - Quantitative platelet disorders and angiopathies 1E - Consultative hematology Select a subchapter 2A - Myeloproliferative and myelodysplastic neoplasms 2B - Acute myeloid leukemia (AML) and leukemias of ambiguous lineage 2C - Pediatric myeloid disorders Select a subchapter 2A - Different types of sickle cell disease 2B - Prevalence in different countries 2C - Changing prevalence in Europe with population growth and movement 2D - Predicted changes in sickle cell disease prevalence 2E - Malaria and natural selection in sickle cell disease 2F - Life expectancy in sickle cell disease 2G - Genetic determinants of variability 2H - Environmental determinants of variability Select a subchapter 2A - Myeloproliferative neoplasms 2B - Myelodysplastic/myeloproliferative neoplasms 2C - Myelodysplastic syndromes (mds) and pre-malignant clonal cytopenias 2D - Acute myeloid leukemia (aml) 2E - Pediatric myeloid disorders Select a subchapter 3A - B-cell neoplasms and B-cell disorders 3B - T-cell lymphomas and NK-cell neoplasms 3C - Hodgkin lymphoma 3D - Other special entities 3E - Plasma cell neoplasms 3F - Pediatric lymphoid malignancies Select a subchapter 3A - History and examination 3B - Laboratory values 3C - Blood film appearances 3D - Hemoglobin analysis 3E - DNA analysis 3F - Prenatal diagnosis Select a subchapter 3A - B-cell neoplasms and other B-cell disorders 3B - T-cell lymphomas and Natural Killer (NK)-cell neoplasms 3C - Hodgkin lymphoma 3D - Special entities 3E - Plasma cell neoplasms 3F - Pediatric lymphoid malignancies Select a subchapter 4A - Principles of treatment 4B - Stem cell transplantation and other cellular therapies 4C - Infectious complications 4D - Supportive and emergency care 4E - Pharmacology and pharmacovigilance Select a subchapter 4A - National screening programs 4B - Antenatal screening 4C - Neonatal screening 4D - Screening in schools, premarital screening and other approaches 4E - Selective screening using ethnicity Select a subchapter 4A - Principles of treatment 4B - Stem cell transplantation and other cellular therapies 4C - Prevention and treatment of infectious diseases 4D - Supportive and emergency care 4E - Pharmacology and pharmacovigilance Select a subchapter 5A - Good laboratory practice 5B - Blood count and morphology 5C - Other laboratory techniques 5D - Immunophenotyping by flow cytometry 5E - Genetics and molecular biology 5F - Coagulation 5G - Immunohematology Select a subchapter 5A - General management of acutely ill patients 5B - Acute pain 5C - Acute chest syndrome 5D - Acute neurological symptoms including stroke 5E - Acute splenic sequestration 5F - Parovirus B19 infection 5G - Invasive pneumococcal disease 5H - Osteomyelitis ans septic arthritis 5I - Acute abdominal sickling 5J - Acute liver complications including cholecystitis Priapism 5K - Hematuria and acute renal problems 5L - Acute loss of vision and orbital sickling 5M - Venous thromboembolic disease Select a subchapter 5A - Good laboratory practice 5B - Blood count and morphology 5C - Immunophenotyping by flow cytometry 5D - Genetics and molecular biology 5E - Coagulation 5F - Immunohematology 5G - Other laboratory techniques Select a subchapter 6A - Acquired bleeding disorders 6B - Congenital bleeding disorders 6C - Thrombotic disorders Select a subchapter 6A - Chronic pain 6B - Chronic splenomegaly 6C - Avascular joint necrosis 6D - Leg ulcers 6E - Chronic renal impairment 6F - Chronic lung disease 6G - Pulmonary hypertension 6H - Progressive hepatopathy 6I - Retinopathy 6J - Silent cerebral infarction Select a subchapter 6A - General Aspects 6B - Acquired bleeding disorders 6C - Congenital bleeding disorders 6D - Thrombotic disorders Select a subchapter 7A - Blood donation 7B - Clinical use of blood components 7C - Specific techniques Select a subchapter 7A - Growth and development 7B - Dactylitis 7C - Nocturnal enuresis 7D - Pica 7E - Acute febrile illnesses 7F - Primary stroke prevention and transcranial Doppler screening 7G - Penicillin and prophylaxis against infections 7H - Vaccinations Select a subchapter 7A - Blood donation 7B - Clinical use of blood components 7C - Apheresis Select a subchapter 8A - Basic biological concepts 8B - Evidence-based medicine 8C - Good medical practice and clinical trials 8D - Ethics and law 8E - Communication skills and psychosocial issues 8F - Palliative care and End-of-life Select a subchapter 8A - Organization of transition service 8B - Inpatient care of teenagers and young adults 8C - Outpatient care of teenagers and young adults Select a subchapter 8A - Basic biological concepts 8B - Evidence-based medicine 8C - Good medical practice and clinical trials 8D - Ethics and law 8E - Communication skills and psychosocial issues 8F - Palliative care and End-of-life Select a subchapter 9A - Contraception 9B - Antenatal management 9C - Perinatal management Select a subchapter 10A - Risks associated with different types of surgery 10B - Preoperative management including blood transfusion 10C - Postoperative management Select a subchapter 11A - Complications of sickle cell disease in old age Select a subchapter 12A - Psychological complications of sickle cell disease 12B - Psychological management of chronic pain Select a subchapter 13A - Socioeconomic factors 13B - Climate 13C - Air quality 13D - Altitude 13E - Travel including air flight 13F - Sports and exercise 13G - Ethno-cultural factors 13H - Patient advocacy and support groups Select a subchapter 14A - Penicillin prophylaxis 14B - Vaccination against pneumococcal disease 14C - Vaccination against meningococcal disease 14D - Vaccination against influenza 14E - Other vaccinations Select a subchapter 15A - Transcranial Doppler screening 15B - Magnetic resonance imaging 15C - Prophylactic blood transfusions 15D - Hydroxyurea Select a subchapter 16A - Mechanisms of action 16B - Side effects 16C - Indications and guidelines for use 16D - Dosing and monitoring Select a subchapter 17A - Selection of blood for patients with sickle cell disease 17B - Indications for acute blood transfusion 17C - Indications for regular blood transfusions 17D - Complications 17E - Exchange blood transfusion 17F - Monitoring of patients on regular blood transfusions 17G - Assessment of transfusional iron overload 17H - Iron chelation 17I - Management of patients refusing blood transfusion Select a subchapter 18A - HSCT from HLA identical siblings 18B - HSCT from unrelated and haploidentical donors Select a subchapter 19A - Drugs increasing HbF levels 19B - Drugs reducing abnormal adhesion of blood cells to vascular endothelium 19C - Drugs reducing inflammatory response 19D - Drugs reducing oxidative stress 19E - Drugs inhibiting HbS polymerization 19F - Drugs reducing red cell dehydration 19G - Other drugs 19H - Gene therapy Select a subchapter 20A - African countries 20B - India 20C - Other countries Select a subchapter 21A - Pathophysiology 21B - Natural history of HbSC disease 21C - Retinopathy 21D - Management of HbSC disease Select a subchapter 22A - HbS/Beta^0 thalassemia 22B - HbS/Beta+ thalassemia 22C - HbS/Delta Beta thalassemia 22D - HbSE disease Select a subchapter 23A - HbS/HPFH 23B - HbS/D-Punjab 23C - HbS/O-Arab 23D - HbS/C-Harlem 23E - HbS-Oman 23F - Others Select a subchapter 24A - Risks of extreme physical exercise and dehydration 24B - Renal disease 24C - Splenic infarction